Papers on liver fibrosis

464 papers29 new in 30 days

Friday, August 8

ResearchAug 8

Dual Roles of SIRT7 Inhibition by Oroxylin A Reprogram HSCs Fate: PRMT5 Succinylation-Driven Senescence and Ecto-Calreticulin-Dependent NK Cell Immune Clearance in Liver Fibrosis

Experiments in animalsLiver fibrosis

Paper

Thursday, August 7

Physiological ReportsAug 7

Elimination of hepatocyte-derived DPP4 downregulates cardiac immune- and collagen-related genes but does not alter cardiac function in aged male mice

Experiments in miceImmune response

Paper

Thursday, July 24

NutrientsJul 24

Beyond Weight Loss: Comparative Effects of Tirzepatide Plus Low-Energy Ketogenic Versus Low-Calorie Diet on Hepatic Steatosis and Stiffness in MASLD

Non-randomized trial in 60 peopleTirzepatide

Paper

Thursday, July 17

Life SciencesJul 17

Time-restricted feeding attenuates hepatic inflammation and enhances muscular endurance of biliary cirrhotic rats

Experiments in ratsDietary restriction

Paper

Monday, July 7

Liver ResearchJul 7

Stem cell-based therapeutic strategies for liver aging

ReviewInterventions

Paper

Saturday, July 5

Hepatology ResearchJul 5

Effect of Tirzepatide Treatment on Hepatic Biomarkers in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease and Type 2 Diabetes Mellitus

Non-randomized trial in 16 peopleTirzepatide

Paper

Friday, July 4

Materials Today BioJul 4

Reprogramming cellular senescence of hepatic stellate cells to combat liver fibrosis by targeted nanodrugs

Experiments in animalsLiver fibrosis

Paper

Thursday, July 3

Scientific ReportsJul 3

Association between liver fibrosis scores and cardiovascular disease in elderly based on NHANES 1999-2018

Cross-sectional study of 18,902 peopleCardiovascular disease

Paper

Cell Reports MedicineJul 3

Cardiolipin-mimic lipid nanoparticles without antibody modification delivered senolytic in vivo CAR-T therapy for inflamm-aging

Experiments in animalsInterventions

Paper

Friday, June 27

European Journal of Gastroenterology & HepatologyJun 27

Identification of high-risk group for diabetes-associated hepatocellular carcinoma using noninvasive test for liver fibrosis

Case-control study in peopleHepatocellular carcinoma

Paper

Biological Trace Element ResearchJun 27

The Effects of Co-administration of Lithium and Vitamin E on Hepatic Oxidative Status in Aged Male and Female Rats: Biochemical and Histomorphological Evaluations

Experiments in 48 ratsVitamin E

Paper

Sunday, June 22

Journal of HepatologyJun 22

Efficacy and safety of time-restricted eating in metabolic dysfunction-associated steatotic liver disease

Randomized trial in 333 peopleDietary restriction

Paper

Tuesday, June 17

Clinical Nutrition ESPENJun 17

Relationship between metabolic dysfunction-associated steatotic liver disease and sarcopenia: A systematic review and meta-analyses

Meta-analysis of observational studiesMetabolic dysfunction-associated steatotic liver disease

Paper

Friday, June 13

ADA Scientific Sessions 2025 AbstractJun 13

Liver Fibrosis Predicts Mortality in Type 2 Diabetes (T2D) Independently of Obesity and A1C

Cohort study of 808 peopleLiver fibrosis

Paper

Thursday, May 29

bioRxivMay 29

Tirzepatide reduces diet-induced senescence and NETosis-mediated liver fibrosis in mice

Preprint: experiments in miceTirzepatide

Paper

Wednesday, May 28

Frontiers in AgingMay 28

Association of sarcopenia and physical activity on the severity of metabolic dysfunction-associated steatotic liver disease among United States adults: NHANES 2017 - 2018

Cross-sectional study of 1,831 peopleMetabolic dysfunction-associated steatotic liver disease

Paper

BiomedicinesMay 28

Bioinformatics-Guided Experimental Validation Identifies NQO1 as a Senescence-Ferroptosis Hub in Liver Fibrosis

Experiments in human cellsFerroptosis

Paper

Tuesday, May 27

Scientific ReportsMay 27

MOTS-c mimics exercise to combat diabetic liver fibrosis by targeting Keap1-Nrf2-Smad2/3

Experiments in ratsAerobic exercise

Paper

Monday, May 26

Frontiers in EndocrinologyMay 26

Case Report: Amelioration of severe metabolic dysfunction-associated steatohepatitis after switching from conventional GLP-1RAs to tirzepatide

Case reportTirzepatide

Paper

Thursday, May 22

PLOS Neglected Tropical DiseasesMay 22

ADSCs attenuate Liver fibrosis via inducing HSC senescence: validation in dual-etiology models

Experiments in miceLiver fibrosis

Paper

Tuesday, May 20

The Journals of Gerontology, Series AMay 20

Higher Circulating Alpha-klotho Levels Increase All-cause Mortality Through Mediation Effects of Liver Fibrosis: A Second Analysis of National Health and Nutrition Examination Survey

Cohort study in peopleLiver fibrosis

Paper

Monday, May 12

PreprintMay 12

IL-10-induced senescence of HSCs enhances the activation and cytotoxicity of NK cells via NKG2D pathway to attenuate liver fibrosis in vivo and vitro

Preprint: experiments in miceCellular senescence

Paper

Tuesday, May 6

Life SciencesMay 6

Exploring the double-edged role of cellular senescence in chronic liver disease for new treatment approaches

ReviewCellular senescence

Paper

Wednesday, April 30

Journal of the American Chemical SocietyApr 30

Trilocked Photodynamic Senolytic Inducer Potentiating Immunogenic Senescent Cell Removal for Liver Fibrosis Resolution

Experiments in animalsLiver fibrosis

Paper

Internal MedicineApr 30

Impact of the FIB4 Index on Pre-sarcopenia in Patients with Metabolic-dysfunction Associated Steatotic Liver Disease

Cross-sectional study in peopleMetabolic dysfunction-associated steatotic liver disease

Paper

Wednesday, April 16

Pharmacological ReviewsApr 16

Antiobesity medications in adult and pediatric obesity and metabolic dysfunction-associated steatotic liver disease

ReviewMetabolic dysfunction-associated steatotic liver disease

Paper

Friday, April 11

JHEP ReportsApr 11

Pravastatin reduces all-cause mortality in elderly individuals at risk of liver fibrosis: Post hoc analysis of the PROSPER trial

Randomized trial in 5,804 peopleStatins

Paper

Monday, March 24

Chinese Journal of Natural MedicinesMar 24

NUMB endocytic adaptor protein (NUMB) mediates the anti-hepatic fibrosis effect of artesunate (ART) by inducing senescence in hepatic stellate cells (HSCs)

Experiments in cellsLiver fibrosis

Paper

Saturday, March 22

bioRxivMar 22

Spatial Transcriptomic Signature of Progressive Fibrosis in Human MASLD: Role of Senescence and Metabolic Reprogramming

Preprint: cross-sectional study of 33 peopleOxidative phosphorylation

Paper

Wednesday, March 19

European Journal of PharmacologyMar 19

Irisin attenuates liver fibrosis by regulating energy metabolism and HMGB1/β-catenin signaling in hepatic stellate cells

Experiments in ratsLiver fibrosis

Paper