Silibinin
Intervention1 paper3 findingsPubChem 31553ChEBI 9144
- Model organisms1
Outcomes
3Lifespan
upin worms1Very low certainty
1 study
Lifespan
upin worms1Very low certainty
Silibinin extends lifespan in worms.
Model organismsin C. elegans
Silibinin Ameliorated Lipid Accumulation Through Insulin/IGF-1 signaling Pathway in HGI C. elegans · The Journal of nutritional biochemistry · 12 Sep 2026
Lipid droplets
downin worms1Very low certainty
1 study
Lipid droplets
downin worms1Very low certainty
Silibinin decreases lipid droplets in worms.
Model organismsliver and EWATs
Silibinin Ameliorated Lipid Accumulation Through Insulin/IGF-1 signaling Pathway in HGI C. elegans · The Journal of nutritional biochemistry · 12 Sep 2026
Fat accumulation
downin worms1−49%Very low certainty
1 study
Fat accumulation
downin worms1−49%Very low certainty
Silibinin decreases fat accumulation in worms (-49%).
Model organismshigh glucose-induced
Silibinin Ameliorated Lipid Accumulation Through Insulin/IGF-1 signaling Pathway in HGI C. elegans · The Journal of nutritional biochemistry · 12 Sep 2026