Biochimica et Biophysica Acta Molecular Basis of Disease
Low cell-attachment protein levels linked to heart aging in mice
Mice with one working copy of the protein’s gene had enlarged, scarred hearts and poorer pumping, resembling changes in aged mice.Mice with one working copy of the protein’s gene had enlarged, scarred hearts and poorer pumping, resembling changes in aged mice.
Mouse studyMechanisms
Who was studiedAged mice and Cdon+/- mice
What changedAged mice had lower CDON levels alongside enlarged hearts, scarring, and poorer pumping
The catchCDON overexpression was assessed through cell senescence, not heart pumping in mice