Papers on large CHIP

12 papers3 new in 30 days

Monday, October 26

ESC Congress 2026 AbstractOct 26

Blood mutations linked to heart, kidney, and metabolic disease

Participants with age-related expansion of mutated blood cells had an adjusted hazard ratio of 1.11 for progression to syndrome stage 4 compared with participants without…Participants with age-related expansion of mutated blood cells had an adjusted hazard ratio of 1.11 for progression to syndrome stage 4 compared with participants without the condition.

Blood cells cluster densely beside a thick-walled heart and scarred kidney, while fewer cells sit near smaller, intact heart and kidney sections.

Cohort · 433,924 peopleStage 4 cardiovascular-kidney-metabolic syndrome

Friday, October 23

Frontiers in EndocrinologyOct 23

Large groups of mutated blood cells linked to cardiovascular death

Large mutated blood-cell groups were linked to a higher relative rate of cardiovascular death: a hazard ratio of 1.24 versus people without the condition.Large mutated blood-cell groups were linked to a higher relative rate of cardiovascular death: a hazard ratio of 1.24 versus people without the condition.

Cohort · 288,384 peopleMechanisms

Thursday, October 1

medRxivOct 1

ASXL1-mutant clonal hematopoiesis links to aortic valve disease

In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or IL-6 inhibition.In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or IL-6 inhibition.

Multivariable-adjusted associations of CHIP and key CHIP subtypes with incident aortic stenosis in the UK Biobank Forest plot of hazard ratios for risk of incident aortic stenosis by CHIP status in…

Preprint: cohort study of 449,109 peopleASXL1

Sunday, August 30

European Heart JournalAug 30

Clonal haematopoiesis and cardiovascular-kidney-metabolic syndrome: a cohort study

Cohort study of 451,460 peopleCardiovascular-kidney-metabolic syndrome

Sunday, August 23

Research SquareAug 23

Genetic βAR Signaling Modifies Clonal Hematopoiesis-Associated Mortality in Patients with Atherosclerotic Cardiovascular Disease

Preprint: cohort study of 10,333 peopleAtherosclerotic cardiovascular disease

Tuesday, August 18

CirculationAug 18

Association of Clonal Hematopoiesis With Silent Brain Lesions and Cognitive Decline in Patients With Atrial Fibrillation

Cohort study of 1,572 peopleMechanisms

Monday, June 1

medRxivJun 1

Association of Clonal Hematopoiesis with Total and Cause-Specific Mortality Among Older Women

Preprint: study in peoplePopulations

Thursday, March 26

Experimental HematologyMar 26

Association of infection frequency and incident clonal hematopoiesis of indeterminant potential

Cohort study of 3,367 peopleInfection

Monday, November 3

AHA Scientific Sessions 2025 AbstractNov 3

Multi-omic Characterization of Clonal Hematopoiesis of Indeterminate Potential (CHIP) in the ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) Trials Biorepository

Cohort study of 507 peopleBlood and immune system

Monday, September 1

JAMA CardiologySep 1

Clonal Hematopoiesis and Risk of New-Onset Myocarditis and Pericarditis

Study in peoplePopulations

Sunday, November 12

European Heart JournalNov 12

Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias

Study in peoplePopulations

Tuesday, May 23

Journal of the American College of CardiologyMay 23

Clonal Hematopoiesis of Indeterminate Potential Predicts Adverse Outcomes in Patients With Atherosclerotic Cardiovascular Disease

Cohort study of 13,129 peopleBlood and immune system