C-terminal agrin fragment

1. Physical activity decreases C-terminal agrin fragment in humans.

   “Active men had lower CAF levels than inactive men, particularly after age 70.”

   Humansmales

   Serum C-terminal agrin fragment as a biomarker of age-related neuromuscular decline in men: influence of physical activity · bioRxiv · 7 Sep 2026 · Preprint

Physical activity →

1. Sex has no effect on C-terminal agrin fragment in humans.

   Humansin healthy adultsn = 120

   Assay-specific reference intervals and evaluation of key preanalytical factors for C-terminal agrin fragment measured using the Abcam ab216945 ELISA · Clinica chimica acta; international journal of clinical chemistry · 26 Aug 2026

1. C-terminal agrin fragment is associated with maximal voluntary isometric contraction in humans.

   “Higher CAF was associated with lower MVIC, lower-limb power and poorer performance on all functional tests.”

   Humansmalesn = 136

   Serum C-terminal agrin fragment as a biomarker of age-related neuromuscular decline in men: influence of physical activity · bioRxiv · 7 Sep 2026 · Preprint

1. C-terminal agrin fragment is associated with NCAM-positive fibers in humans.

   “Serum CAF increased with age and was positively associated with NCAM-positive fiber proportion.”

   Humansmalesn = 136

   Serum C-terminal agrin fragment as a biomarker of age-related neuromuscular decline in men: influence of physical activity · bioRxiv · 7 Sep 2026 · Preprint

NCAM-positive fibers →

1. Age is associated with C-terminal agrin fragment in humans.

   Humansin lithium-heparin plasma of healthy adultsn = 120

   Assay-specific reference intervals and evaluation of key preanalytical factors for C-terminal agrin fragment measured using the Abcam ab216945 ELISA · Clinica chimica acta; international journal of clinical chemistry · 26 Aug 2026