Journal of Orthopaedic Translation
Dihydroartemisinin ameliorates hemarthrosis-induced cartilage degeneration by suppressing chondrocyte senescence via activation of Keap1-Nrf2 signaling pathway
Experiments in miceBones and joints
Papers on Keap1
127 papers6 new in 30 days
Wednesday, July 23
Tuesday, July 22
Journal of Neuroimmunology
Fisetin alleviates Aβ-induced neuronal cell ferroptosis by regulating Sirt6-mediated deacetylation modification
Experiments in mouse cellsFisetin
Sunday, July 13
Biogerontology
Sex-dependent geroprotective effects of malvidin in Drosophila melanogaster
Experiments in fliesInterventions
Tuesday, June 24
Drug Design, Development and Therapy
Design, Synthesis, and Evaluation of Nitroxide Radical Derivatives Based on Rhein as Potential Anti-Aging Agents Targeting the Keap1-Nrf2 Pathway
Experiments in wormsInterventions
Tuesday, May 27
Scientific Reports
MOTS-c mimics exercise to combat diabetic liver fibrosis by targeting Keap1-Nrf2-Smad2/3
Experiments in ratsAerobic exercise
Thursday, May 22
Gene
Genetic predictors of longevity and survival in cellular homeostasis genes: A case-control study
Cohort study of 3,312 peoplePopulations
Monday, May 19
European Journal of Pharmacology
Ameliorative effect of GLP1 agonist on vascular calcification in normoglycemic aged rat aorta via miR34a/SIRT6/NRF2/HO-1 signalling pathway
Experiments in 24 ratsGLP-1 receptor agonists
Thursday, April 24
Thursday, April 3
Wednesday, January 29
Redox Biology
Norharmane prevents muscle aging via activation of SKN-1/NRF2 stress response pathways
Experiments in wormsMuscle
Tuesday, January 28
Life Medicine
DDO1002, an NRF2-KEAP1 inhibitor, improves hematopoietic stem cell aging and stress response
Experiments in miceBlood and immune system
Saturday, January 25
Monday, January 13
Friday, December 13
Monday, September 9
Phytomedicine
Lutein protects senescent ciliary muscle against oxidative stress through the Keap1/Nrf2/ARE pathway
Experiments in animalsMuscle
Saturday, August 31
International Journal of Molecular Sciences
Citrus Flavanone Effects on the Nrf2-Keap1/GSK3/NF-κB/NLRP3 Regulation and Corticotroph-Stress Hormone Loop in the Old Pituitary
Experiments in ratsInterventions
The Journal of Nutritional Biochemistry
Paternal exercise induces antioxidant defenses by α-Klotho/Keap1 pathways in the skeletal muscle of offspring exposed to a high fat-diet without changing telomere length
Experiments in ratsResistance training
Saturday, August 10
Redox Biology
Loss of NAMPT and SIRT2 but not SIRT1 attenuate GLO1 expression and activity in human skeletal muscle
Cross-sectional study in peopleSirtuin signaling
Tuesday, June 25
Reproductive Medicine and Biology
KEAP1-NRF2 system regulates age-related spermatogenesis dysfunction
Experiments in animalsMechanisms
Thursday, May 23
Wednesday, May 22
Wednesday, May 8
Research Square
Lifespan extension of Caenorhabditis elegans by sulforafane: Sulforafane induces Nrf2 (cSKN-1) via WDR23, but not keap1
Preprint: experiments in wormsInterventions
Sunday, March 24
Molecular Nutrition & Food Research
Potential Function of 3,5-Dihydroxy-4-Methoxybenzyl Alcohol from Pacific Oyster (Crassostrea gigas) in Brain of Old Mice
Experiments in miceInterventions
Tuesday, March 19
The European Journal of Neuroscience
Homocysteine-potentiated Kelch-like ECH-associated protein 1 promotes senescence of neuroblastoma 2a cells via inhibiting ubiquitination of β-catenin
Experiments in mouse cellsCellular senescence
Saturday, February 24
Monday, November 27
Advances in Gerontology
Polyphenols of natural origin against age-related disorders of tissue homeostasis
ReviewPolyphenols
Monday, November 13
Scientific Reports
The role of MOTS-c-mediated antioxidant defense in aerobic exercise alleviating diabetic myocardial injury
Experiments in ratsAerobic exercise
Friday, October 13
Molecular and Cellular Biochemistry
Metformin modulates mitochondrial autophagy in renal tubular epithelial injury induced by high glucose via the Keap1/Nrf2 pathway
Experiments in miceMetformin
Saturday, September 9
International Journal of Molecular Sciences