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K48 polyubiquitinated protein accumulation

Biomarker

1 paper1 finding

  • Animals1

Upstream

1

FOXO1/FOXO3/FOXO4

upin mice1

1 study

  1. FOXO1/FOXO3/FOXO4 increases K48 polyubiquitinated protein accumulation in mice.

    “accumulation of K48 polyubiquitinated proteins were observed in quad and TA but were prevented by FoxO deletion.”

    Animalsshown by muscle-specific FoxO1/3/4 triple knockoutquadriceps and tibialis anterior

    Loss of FoxOs in muscle increases strength and mitochondrial function during aging

    Journal of cachexia, sarcopenia and muscle28 Nov 2022

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