Intestinal stem cell count

2 papers2 findings

Animals1
Model organisms1

Upstream

2

RGN

downin flies1

1 study

RGN decreases intestinal stem cell count in flies.
“Rgn deficiency in progenitors disrupts Notch signaling, resulting in the depletion of ISCs and the accumulation of enteroblasts (EBs).”
Model organismsRgn deficiency in progenitorsintestine
Rgn couples proliferative EGFR-JAK/STAT signaling and the notch/insulin differentiation-metabolism axis during epithelial repair in Drosophila
Insect biochemistry and molecular biology2 Apr 2026

ERCC1

downin mice1

1 study

ERCC1 decreases intestinal stem cell count in mice.
“Nevertheless, we found apoptosis and reduced numbers of intestinal stem cells (ISCs)”
Animalsin Ercc1Δ/- mutantssmall intestine
Different responses to DNA damage determine ageing differences between organs
Aging cell4 Mar 2022

Latest

1 in 12 months

Insect Biochemistry and Molecular Biology2 Apr

Rgn couples proliferative EGFR-JAK/STAT signaling and the notch/insulin differentiation-metabolism axis during epithelial repair in Drosophila

Experiments in fliesNotch signalling

Aging Cell4 Mar

Different responses to DNA damage determine ageing differences between organs

Experiments in miceDNA damage response