Horvath age acceleration

1. Horvath age acceleration has no effect on dementia in humans.

   “The other epigenetic age estimators were not associated with incident MCI/dementia.”

   Humansmedian follow-up of 9.3 yearsfemalesn = 5,923

   Prospective associations of epigenetic age estimators with incident mild cognitive impairment and dementia among older women: The Women's Health Initiative Memory Study

   AAIC 2025 abstract·24 Dec 2025

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1. Allostatic load is associated with Horvath age acceleration in humans.

   “AL was more strongly associated with EAA in men compared with women as assessed using Horvath's clock.”

   Humansmales

   Epigenetic Clocks and Allostatic Load Reveal Potential Sex-Specific Drivers of Biological Aging

   The journals of gerontology. Series A, Biological sciences and medical sciences·14 Feb 2020

2. Horvath age acceleration is associated with allostatic load in humans (r = 0.05).

   “Horvath, Hannum, and Levine EAA correlated 0.05, 0.03, and 0.21 with AL, respectively.”

   Humans

   Epigenetic Clocks and Allostatic Load Reveal Potential Sex-Specific Drivers of Biological Aging

   The journals of gerontology. Series A, Biological sciences and medical sciences·14 Feb 2020

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