Hippocampal functional connectivity

1. APOE decreases hippocampal functional connectivity in humans.

   “APOE4 non‐carriers had significantly greater activation and hippocampal functional connectivity in several regions compared to APOE4 carriers”

   Humanscognitively normalbrainfemalesn = 145

   Evidence of Early APOE4‐ Related Vulnerabilities in Memory Systems in Midlife Women

   AAIC 2025 abstract·24 Dec 2025

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1. Centrum semiovale perivascular space volume fraction increases hippocampal functional connectivity in humans.

   “Increased CSO-PVS VF in early middle-aged adults showed higher hippocampal FC and better cognitive performance.”

   Humans

   Perivascular space mediated the interaction between sleep, and brain functional connectivity in the healthy aging population

   bioRxiv : the preprint server for biology·21 May 2025Preprint

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1. Hippocampal functional connectivity predicts episodic memory decline in humans.

   “higher connectivity within the hippocampus attenuated the negative association between temporal-lobe tau burden and memory performance but predicted unfavorable memory trajectories.”

   Humanshigher connectivity within the hippocampusn = 75

   Mesoscale medial temporal lobe connectivity patterns relate to tau pathology and memory in older adults

   bioRxiv·21 Aug 2026Preprint

1. APOE is associated with hippocampal functional connectivity in humans.

   “APOE4 + status modified the association of estradiol with both left and right HippfConn during encoding.”

   Humansbrainfemalesn = 172

   Associations of Estradiol and APOE4 Genotype with Hippocampal Connectivity during Verbal Encoding in Postmenopausal Women

   AAIC 2025 abstract·11 Jan 2026

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1. Diet is associated with hippocampal functional connectivity in humans (left hippocampus: 9176 mm3, P < .05; left hippocampus and to the right cerebellum: 136 mm3, P = .04).

   “Better diet quality in midlife and from midlife to late life was associated with higher hippocampal functional connectivity to the occipital lobe and cerebellum”

   HumansWhitehall II Imaging Substudyn = 512

   Association of Diet and Waist-to-Hip Ratio With Brain Connectivity and Memory in Aging

   JAMA network open·3 Mar 2025

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