Amyloid-beta 42/40

Amyloid-beta 42/40 has no effect on cognitive function composite score in humans.

“No significant associations were found between Aβ42/40 and changes in the other five cognitive domains or the composite score.”

Humans5 to 7 yearsn = 250

Association Between Decline in Cognitive Processing Speed and CSF Amyloid‐β 42/40 in Cognitively Healthy Older Adults Aged 70, Followed over 5 to 7 Years: Data from the Gothenburg H70 Birth Cohort Study

AAIC 2025 abstract·25 Dec 2025

Amyloid-beta 42/40 is associated with cognitive processing speed in humans (β 0.123; 95% CI [0.018 – 1.042]).

“Lower levels of Aβ42/40 were associated with a steeper decline in processing speed over the follow‐up period (β 0.123; 95% CI [0.018 – 1.042]).”

Humanscerebrospinal fluid5 to 7 yearsn = 250

Association Between Decline in Cognitive Processing Speed and CSF Amyloid‐β 42/40 in Cognitively Healthy Older Adults Aged 70, Followed over 5 to 7 Years: Data from the Gothenburg H70 Birth Cohort Study

AAIC 2025 abstract·25 Dec 2025