Mesoscale medial temporal lobe connectivity patterns relate to tau pathology and memory in older adults
bioRxiv
Abstract
The medial temporal lobe (MTL) is crucial for episodic memory. Tau pathology is a hallmark of Alzheimer's disease (AD) and accumulates in layer-specific patterns in the MTL during aging. It is, however, unclear whether early AD pathology relates to mesoscale network signatures distinct from non-pathological aging.
The paper
Larissa Fischer, Niklas Vockert, Joseph Höpker Fernandes, Anne Maaß
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Berta Garcia‐Garcia, Sebastian Niclas Roemer, Nicolai Franzmeier, Helena Marie Gellersen, Beate Schumann‐Werner, Niklas Behrenbruch, Svenja Schwarck, Eóin N. Molloy, Gusalija Behnisch, Constanze I. Seidenbecher, Björn Hendrik Schott, Bárbara Morgado, Hermann Esselmann, Jens Wiltfang, Henryk Barthel, Osama Sabri, Michael Christoph Kreissl, Emrah Düzel, Stefanie Schreiber, Esther Kuehn,German Center for Neurodegenerative Diseases
bioRxiv · 21 Aug 2026 · CC BY · Preprint, not peer-reviewed
