Hematology

Biomarker

1 paper

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BMC Geriatrics

Red blood cell variation is linked to higher hip fracture risk

Each one-percentage-point increase in red blood cell distribution width was linked to an 8% higher hazard of hip fracture over 14 years.Each one-percentage-point increase in red blood cell distribution width was linked to an 8% higher hazard of hip fracture over 14 years.

Cohort study of 76,078 peopleHip fracture
Biogerontology

A metabolic protein promotes blood stem cell aging in mice

In mice, genetically removing the protein reduced signs of cellular aging across multiple tissues and limited hallmarks of blood stem cell aging.In mice, genetically removing the protein reduced signs of cellular aging across multiple tissues and limited hallmarks of blood stem cell aging.

Experiments in miceMechanisms
HemaSphere

Blood-cell mutation patterns linked to cancer progression

A yearly rise of at least 7.5% in mutated gene copies’ share best predicted cancer progression among patients with unexplained low counts of certain white blood cells.A yearly rise of at least 7.5% in mutated gene copies’ share best predicted cancer progression among patients with unexplained low counts of certain white blood cells.

Cohort study of 256 peopleBiomarkers
bioRxiv

TET deficiency drives selection of aneuploid cells in mice

In mice and mouse cells, disrupting TET enzymes allowed rare pre-existing aneuploid subclones, including chromosome 17 trisomy, to dominate during rapid cellular…In mice and mouse cells, disrupting TET enzymes allowed rare pre-existing aneuploid subclones, including chromosome 17 trisomy, to dominate during rapid cellular expansion.

Preprint: experiments in miceMechanisms