Guanosine
1 paper1 finding
- Cells1
Interventions
1Isonicotinamide
downin yeast cells1
1 study
Isonicotinamide
downin yeast cells1
Isonicotinamide decreases guanosine in yeast cells.
“INAM causes dose-dependent depletion of intracellular cytidine, uridine, and guanosine”
Cellsdose-dependent
The Journal of biological chemistry13 Jan 2026
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The Journal of Cardiovascular Aging
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Chronological lifespan extension and nucleotide salvage inhibition in yeast by isonicotinamide supplementation
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CHK1 attenuates cardiac senescence of mice through activating Rap1/Nox4 mediated oxidative stress homeostasis
Experiments in 40 miceOxidative stress and ROS signalling
Science
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Experiments in naked mole-ratsDNA repair
Cell & Bioscience
PINK1 functions in mitophagy and mitochondrial homeostasis during mice oocyte maturation
Experiments in cellsMechanisms