Isonicotinamide

1 paper4 findings

PubChem 15074 ChEBI 6031 MeSH C027681

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Israel National Road Safety Authority and 4 more

Cells1

Outcomes

4

Guanosine

downin yeast cells1

1 study

Isonicotinamide decreases guanosine in yeast cells.
“INAM causes dose-dependent depletion of intracellular cytidine, uridine, and guanosine”
Cellsdose-dependent
Chronological lifespan extension and nucleotide salvage inhibition in yeast by isonicotinamide supplementation
The Journal of biological chemistry13 Jan 2026

More on Guanosine

Uridine

downin yeast cells1

1 study

Isonicotinamide decreases uridine in yeast cells.
“INAM causes dose-dependent depletion of intracellular cytidine, uridine, and guanosine”
Cellsdose-dependent
Chronological lifespan extension and nucleotide salvage inhibition in yeast by isonicotinamide supplementation
The Journal of biological chemistry13 Jan 2026

More on Uridine

Cytidine

downin yeast cells1

1 study

Isonicotinamide decreases cytidine in yeast cells.
“INAM causes dose-dependent depletion of intracellular cytidine, uridine, and guanosine”
Cellsdose-dependent
Chronological lifespan extension and nucleotide salvage inhibition in yeast by isonicotinamide supplementation
The Journal of biological chemistry13 Jan 2026

More on Cytidine

Chronological lifespan

upin yeast cells1

1 study

Isonicotinamide extends chronological lifespan in yeast cells.
“INAM also extends yeast chronological lifespan, but the underlying mechanisms remain largely uncharacterized.”
Cellssupplementation in growth media
Chronological lifespan extension and nucleotide salvage inhibition in yeast by isonicotinamide supplementation
The Journal of biological chemistry13 Jan 2026

Latest

1 in 12 months

The Journal of Biological Chemistry16 Jan

Chronological lifespan extension and nucleotide salvage inhibition in yeast by isonicotinamide supplementation

Experiments in yeastInterventions

bioRxiv16 Jul

Chronological lifespan extension and nucleotide salvage inhibition in yeast by isonicotinamide supplementation

Preprint: experiments in cellsInterventions