HFI-419
Intervention1 paper3 findings
- Animals1
Outcomes
3Cellular senescence
downin cells1Very low certainty
1 study
Cellular senescence
downin cells1Very low certainty
HFI-419 decreases cellular senescence in cells.
Cellsin vitro under oxidative stressproximal tubule cells
IRAP deficiency preserves renal function and attenuates pathology in aged mice · Clinical science (London, England : 1979) · 3 Sep 2026
Cellular senescence markers
downin mice1Very low certainty
1 study
Cellular senescence markers
downin mice1Very low certainty
HFI-419 decreases cellular senescence markers in mice.
Animalskidney500 ng/kg/min4 weeks
IRAP deficiency preserves renal function and attenuates pathology in aged mice · Clinical science (London, England : 1979) · 3 Sep 2026
Glomerular filtration rate
downin mice1Very low certainty
1 study
Glomerular filtration rate
downin mice1Very low certainty
HFI-419 prevents glomerular filtration rate in mice.
Animalskidney500 ng/kg/min4 weeks
IRAP deficiency preserves renal function and attenuates pathology in aged mice · Clinical science (London, England : 1979) · 3 Sep 2026