Papers on Frailty Risk Score

Who was studied2,588,159 weighted admissions for diabetic foot ulcers, during hospitalization

What changedAmputation odds with versus without revascularization were lower at low frailty (OR 0.30), but not clearly different at highest frailty (1.05)

The catchIschemic severity and procedural suitability affect treatment selection but were inadequately captured

Who was studied63,509 dementia-free UK Biobank participants, 10 years

What changedCombining frailty and brain scans improved dementia risk ranking beyond frailty alone, with a ranking score of 0.825

The catchDementia risk-ranking performance lacks external validation

Who was studied34,260 hospitalizations for cardiogenic shock involving VA-ECMO

What changedHospital deaths were higher with high frailty scores: 49.3% versus 45.6% with low scores

The catchDifferences in illness severity may have contributed to the association despite adjustment

Who was studied60,165 adult hospitalizations for mitral valve edge-to-edge repair, hospital stay

What changedHospital complications occurred in 33.0% of hospitalizations with frailty versus 5.1% without frailty

The catchFrail patients had more coexisting illness and non-elective admissions, potentially explaining some outcome differences

Who was studied97,325 hospitalized adults with chronic lymphocytic leukemia

What changedAdults with high frailty had 4.74 times the adjusted odds of hospital death compared with those with low frailty

The catchDifferences in illness severity could partly explain the link between frailty and hospital death

Who was studied211,548 community-dwelling outpatients with newly diagnosed heart failure, 10 years

What changedDementia risk was higher in heart failure patients than matched people without heart failure (hazard ratio 1.42 at 5 years)

The catchFrailty could confound the association; it predicted dementia and was not a stated matching factor

Who was studiedPatients with acute myocardial infarction, one year, against non-frail patients

What changedFor patients 75 and older, the adjusted odds ratio for in-hospital death was 1.81 in frail against 2.64 in non-frail

The catchFrailty was assessed by an administrative proxy score rather than physical frailty tests

Who was studied7,607 adults with aortic stenosis undergoing first-time TAVI, one-year

What changedDeath from any cause within a year after discharge was 21.5% with home care versus 6.4% without it

Who was studied207,419 adults with cardiogenic shock, against non-frail patients

What changedIn-hospital mortality was higher with frailty: 39.3% versus 29.8% in older and 24.5% versus 16.2% in younger patients

The catchFrailty was determined using a hospital risk score rather than direct physical testing

Who was studied332,438 adults aged 65 or older

What changedEstimated reductions in flu or pneumonia hospitalization with high-dose versus standard-dose vaccine rose from 0.2% to 19.9% across increasing frailty risk

The catchSanofi funded the trial