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Frailty Risk Score

There are 10 papers on Frailty Risk Score in aging research: 10 observational studies in people. The newest story, Nov 12, 2026: “Frailty alters link between blood-flow procedures and amputation”.

Biomarker

10 papers study it371 more mention it11 findings

17 new papers in 30 daysSee all 381 papers on Frailty Risk Score

“The best performing FRS-NF-26-LABS included nursing flowsheet data and blood biomarkers (Adj. HR = 1.30, 95% CI [1.28, 1.33])”
Frailty and In-Hospital Mortality Risk Using EHR Nursing DataBiological research for nursing2021doi:10.1177/10998004211060541
  • Humans10

Effects

1

Length of stay

no changein humans1

1 study

  1. Frailty Risk Score was not clearly linked with length of stay in humans (hospitalized for COVID-19).

    “none of the 3 variables were significantly correlated with length-of-stay.”

    Humanshospitalized for COVID-19n = 56

    Predictors of COVID-19 outcomes: Interplay of frailty, comorbidity, and age in COVID-19 prognosis

    Medicine

Associations

8

Mortality

upin humans2

2 studies

  1. Frailty Risk Score is associated with mortality in humans (hospitalized for COVID-19) (P = .007).

    “Multivariate analysis showed FRS (P = .007) but not patient age (P = .967) was significantly associated with death.”

    Humanshospitalized for COVID-19n = 56

    Predictors of COVID-19 outcomes: Interplay of frailty, comorbidity, and age in COVID-19 prognosis

    Medicine

  2. Frailty Risk Score is associated with mortality in humans (lung transplant candidates/recipients) (p = .047).

    “There was also an association between FRS score and death (p = .047).”

    Humanslung transplant candidates/recipientsn = 84

    Predictive value of chart-based frailty evaluation for lung transplant candidates

    Clinical transplantation

In-hospital mortality

upin humans2HR 1.3–2.27

2 studies

  1. Frailty Risk Score is linked with a higher risk of in-hospital mortality in humans (Adj. HR = 1.30, 95% CI [1.28, 1.33]).

    “The best performing FRS-NF-26-LABS included nursing flowsheet data and blood biomarkers (Adj. HR = 1.30, 95% CI [1.28, 1.33])”

    Humansn = 46,645

    Frailty and In-Hospital Mortality Risk Using EHR Nursing Data

    Biological research for nursing

  2. Frailty Risk Score is associated with in-hospital mortality in humans (Hospitalized patients; association depended on length of stay) (HR 1.77–2.27 for length of stay of 3–7 days).

    “Increased FRS was significantly associated with increased risk of death”

    HumansHospitalized patients; association depended on length of stay3–7 daysn = 278

    Frailty Assessment in Hospitalized Older Adults Using the Electronic Health Record

    Biological research for nursing

Total healthcare expenditures

upin humans1

1 study

  1. Frailty Risk Score is associated with total healthcare expenditures in humans (high-risk vs low-risk group) (1.51-fold higher healthcare costs).

    “The high-risk group incurred 3.75-fold higher LTC costs and 1.51-fold higher healthcare costs than the low-risk group.”

    Humanshigh-risk vs low-risk groupfiscal years 2019–2022n = 1,882

    Frailty risk stratification using a senior volunteer-driven frailty check-up and subsequent long-term care and healthcare expenditures: A cohort study

    Archives of Gerontology and Geriatrics Plus

Long-term care costs

upin humans1

1 study

  1. Frailty Risk Score is associated with long-term care costs in humans (high-risk vs low-risk group) (3.75-fold higher LTC costs).

    “The high-risk group incurred 3.75-fold higher LTC costs and 1.51-fold higher healthcare costs than the low-risk group.”

    Humanshigh-risk vs low-risk groupfiscal years 2019–2022n = 1,882

    Frailty risk stratification using a senior volunteer-driven frailty check-up and subsequent long-term care and healthcare expenditures: A cohort study

    Archives of Gerontology and Geriatrics Plus

Intensive care unit transfer

upin humans1

1 study

  1. Frailty Risk Score predicts intensive care unit transfer in humans (medical-surgical inpatients).

    “all FRS measures significantly predicted time to first ICU transfer.”

    Humansmedical-surgical inpatients

    Using EHR Data to Identify Patient Frailty and Risk for ICU Transfer

    Western journal of nursing research

Frailty

upin humans1

1 study

  1. Frailty Risk Score predicts frailty in hospitalized HFrEF patients (PPV 83%, NPV 72%, specificity 97% at 5 points; NPV 94% at ≤2 points).

    “The presented novel, simple score predicts FS in HFrEF patients with routine clinical parameters and has good positive and negative predictive values.”

    Humansin hospitalized HFrEF patientsn = 153

    A Simple Risk Score Based on Routine Clinical Parameters Can Predict Frailty in Hospitalized Heart Failure Patients

    Journal of clinical medicine

Hospital readmission

upin humans1

1 study

  1. Frailty Risk Score is associated with hospital readmission in humans (lung transplant candidates/recipients).

    “A high FRS was associated with readmission in the first year after transplantation and with the number of readmissions.”

    Humanslung transplant candidates/recipientsn = 84

    Predictive value of chart-based frailty evaluation for lung transplant candidates

    Clinical transplantation

30-day rehospitalization

upin humans1OR 1.18

1 study

  1. Frailty Risk Score is associated with 30-day rehospitalization in humans (Patients who did not die in hospital) (Adjusted OR 1.18; p = .086).

    “Frailty was marginally associated with rehospitalization for those who did not die in hospital”

    HumansPatients who did not die in hospital30 days

    Frailty Assessment in Hospitalized Older Adults Using the Electronic Health Record

    Biological research for nursing

Latest

Dec 2025: 7Jan 2026: 4Feb 2026: 14Mar 2026: 3Apr 2026: 8May 2026: 6Jun 2026: 3Jul 2026: 5Aug 2026: 3Sep 2026: 6Oct 2026: 11Nov 2026: 878 papers in 12 months
International Wound Journal

Frailty alters link between blood-flow procedures and amputation

The adjusted odds ratio for major amputation with versus without blood-flow procedures was 0.30 with low frailty and 1.05 with high frailty.The adjusted odds ratio for major amputation with versus without blood-flow procedures was 0.30 with low frailty and 1.05 with high frailty.

Cohort · 2,588,159 peoplePopulations
Paper
GeroScience

Brain scans improve dementia risk ranking beyond frailty

A simplified score achieved 0.843 on a measure of risk ranking, while a fuller model outperformed frailty alone over 10 years.A simplified score achieved 0.843 on a measure of risk ranking, while a fuller model outperformed frailty alone over 10 years.

Cohort · 63,509 peopleIncident dementia
Paper
AHA Scientific Sessions 2026 Abstract

Higher frailty linked to hospital deaths on heart-lung support

Deaths occurred in 49.3% of hospitalizations with high frailty scores versus 45.6% with low scores among adults on heart-lung support.Deaths occurred in 49.3% of hospitalizations with high frailty scores versus 45.6% with low scores among adults on heart-lung support.

Cohort · 34,260 peopleBiomarkers
Paper
AHA Scientific Sessions 2026 Abstract

Frailty linked to hospital harm in catheter mitral edge-to-edge repair

Adverse hospital events occurred in 33.0% of hospitalizations with frailty versus 5.1% without frailty for catheter-based mitral valve edge-to-edge repair.Adverse hospital events occurred in 33.0% of hospitalizations with frailty versus 5.1% without frailty for catheter-based mitral valve edge-to-edge repair.

Cohort · 60,165 peopleBiomarkers
Paper
Journal of Geriatric Oncology

Frailty linked to worse outcomes in chronic lymphocytic leukemia

Hospitalized adults with high frailty had 4.74 times the adjusted odds of dying in hospital compared with those with low frailty.Hospitalized adults with high frailty had 4.74 times the adjusted odds of dying in hospital compared with those with low frailty.

Cohort · 97,325 peopleChronic lymphocytic leukemia
Paper
JACC Advances

Heart failure linked to higher dementia risk at ages 40–80

The relative rate of new dementia diagnoses was 1.42 at five years and 1.31 at 10 years compared with matched people without heart failure.The relative rate of new dementia diagnoses was 1.42 at five years and 1.31 at 10 years compared with matched people without heart failure.

Cohort · 211,548 peopleDementia
Paper

See all 381 papers on Frailty Risk Score

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