There are 12 papers on fasting glycemia in aging research: 4 trials and 2 observational studies in people, 4 in animals, 1 review.
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“the effect of overweight and pre-pregnancy hypertension was observed, as well as altered HbA1c in the immediate postpartum period, on the elevation of FG”
- Human trial4
- Humans2
- Animals4
Interventions
5Metformin
downin humans1−18%
1 study
Metformin
downin humans1−18%
Metformin decreases fasting glycemia in humans (-18%).
“After M+, fasting blood glucose, but not serum insulin, was reduced by 18% as compared to M– and plasma lactate concentrations were 48% higher (Fig. 1A, B; Table 2).”
Human trial≥ 2 weeksmalesn = 16
Drugs
Metformin decreases fasting glycemia in humans (moderately controlled type 2 diabetes) (-18% versus without metformin).
“M+ reduced fasting glycemia by 18%”
Human trialmoderately controlled type 2 diabetes1 g twice dailymalesn = 16
Drugs
Multidomain lifestyle intervention
downin humans1
1 study
Multidomain lifestyle intervention
downin humans1
Multidomain lifestyle intervention decreases fasting glycemia in humans (facioscapulohumeral dystrophy) (-1.6 mmol/L).
“fasting glycemia (-1.6 mmol/L)”
Human trialfacioscapulohumeral dystrophyone yearmalesn = 1
Case reports in medicine
Glycine
upin mice1
1 study
Glycine
upin mice1
Glycine increases fasting glycemia in mice (high-fat, high-sucrose diet-fed mice).
“glycine supplementation worsened fasting glycemia and glycemic response to intraperitoneal pyruvate injection compared to HFHS”
Animalshigh-fat, high-sucrose diet-fed mice300 mg/kg in drinking waterlast 6 weeks of dietmales
Nutrients
Dietary protein restriction
upin rats1
1 study
Dietary protein restriction
upin rats1
Dietary protein restriction increases fasting glycemia in rats (regardless of estrogen status).
“moderate dietary protein restriction increases fasting glycemia without modifying insulinemia”
Animalsregardless of estrogen statusmoderately reduced protein intake13 week periodfemales
The Journal of nutritional biochemistry
Cold
downin humans1
1 study
Cold
downin humans1
Cold decreases fasting glycemia in humans (type 2 diabetes).
“reduce fasting glycemia in individuals with type 2 diabetes”
Reviewtype 2 diabetes
Examining the benefits of cold exposure as a therapeutic strategy for obesity and type 2 diabetes
Journal of applied physiology (Bethesda, Md. : 1985)
Upstream
1LMNA
downin mice1
1 study
LMNA
downin mice1
LMNA decreases fasting glycemia in mice (diabetes model in Lmna LCS/LCS mice).
“Lmna LCS/LCS animals normalize their fasting glycemia by both increasing insulin secretion and regenerating β-cells.”
Animalsdiabetes model in Lmna LCS/LCS mice
Lamin C Counteracts Glucose Intolerance in Aging, Obesity, and Diabetes Through β-Cell Adaptation
Diabetes
Associations
3HbA1c
upin humans1
1 study
HbA1c
upin humans1
HbA1c is associated with fasting glycemia in humans (Immediate postpartum HbA1c ≥ 5.7%; low-income women; model adjusted for age and schooling).
“the effect of overweight and pre-pregnancy hypertension was observed, as well as altered HbA1c in the immediate postpartum period, on the elevation of FG”
HumansImmediate postpartum HbA1c ≥ 5.7%; low-income women; model adjusted for age and schoolingblood1 year postpartumfemalesn = 130
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia
Pre-gestational hypertension
upin humans1
1 study
Pre-gestational hypertension
upin humans1
Pre-gestational hypertension is associated with fasting glycemia in humans (Low-income postpartum women; model adjusted for age and schooling).
“the effect of overweight and pre-pregnancy hypertension was observed, as well as altered HbA1c in the immediate postpartum period, on the elevation of FG”
HumansLow-income postpartum women; model adjusted for age and schoolingblood1 year postpartumfemalesn = 130
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia
Pre-gestational overweight
upin humans1
1 study
Pre-gestational overweight
upin humans1
Pre-gestational overweight is associated with fasting glycemia in humans (Low-income postpartum women; model adjusted for age and schooling).
“the effect of overweight and pre-pregnancy hypertension was observed, as well as altered HbA1c in the immediate postpartum period, on the elevation of FG”
HumansLow-income postpartum women; model adjusted for age and schoolingblood1 year postpartumfemalesn = 130
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia