iScience
Fat metabolism linked to muscle problems in aging obese mice
Female mice fed a high-fat diet for seven months developed obesity, but signs of metabolic exhaustion tracked differences in muscle dysfunction rather than obesity…Female mice fed a high-fat diet for seven months developed obesity, but signs of metabolic exhaustion tracked differences in muscle dysfunction rather than obesity severity.
Mouse study · 70 miceLipid and ceramide metabolism
Who was studied70 aging female mice, 7 months, against standard-diet mice
What changedA fat-metabolism signature accounted for 58.4% of the decline in running distance with high-fat versus standard diet
The catchRunning performance also reflects motivation and brain function, not just muscle function