ER-stress markers
3 papers3 findings
- Humans1
- Animals1
- Model organisms1
Interventions
1S88
downin human cells1
1 study
S88
downin human cells1
S88 decreases ER-stress markers in human cells.
“In human SH-SY5Y-derived neurons, S88 improves survival and reduces tunicamycin-induced ER-stress markers.”
Cellstunicamycin-induced ER stressSH-SY5Y-derived neurons
Discovery of a pyrazolopyridine alkaloid that mitigates neuronal ER stress and age-related decline
Communications biology8 May 2026
Upstream
1IL10
downin mice1
1 study
IL10
downin mice1
IL10 decreases ER-stress markers in mice.
“Furthermore, mice lacking IL-10 increased BiP, CHOP, and p-eIF2α/eIF2α protein levels”
AnimalsShown by Il10 knockout; BiP, CHOP, and p-eIF2α/eIF2α protein readoutsskeletal muscle
The role of interleukin-10 in mitigating endoplasmic reticulum stress in aged mice through exercise
American journal of physiology. Endocrinology and metabolism31 Jul 2024
Associations
1Older donor age
upin human cells1
1 study
Older donor age
upin human cells1
Older donor age is associated with ER-stress markers in human cells.
“At baseline, fibroblasts from aging individuals showed increased levels of ER stress (ATF6 and PERK)”
Cellsat baselinelung fibroblast
Endoplasmic reticulum stress-induced senescence in human lung fibroblasts
American journal of physiology. Lung cellular and molecular physiology21 May 2024