S88
- 1 lab in 1 country
- Funders: Chiang Mai University and 3 more
- Model organisms1
Outcomes
3Neuromuscular and locomotor function
upin flies1
1 study
Neuromuscular and locomotor function
upin flies1
S88 improves neuromuscular and locomotor function in flies.
“In Drosophila, S88 ameliorates neuromuscular and locomotor phenotypes in a UBQLN2-associated ALS model and improves aging-related outcomes.”
Model organismsUBQLN2-associated ALS model
Discovery of a pyrazolopyridine alkaloid that mitigates neuronal ER stress and age-related decline
Communications biology8 May 2026
ER-stress markers
downin human cells1
1 study
ER-stress markers
downin human cells1
S88 decreases ER-stress markers in human cells.
“In human SH-SY5Y-derived neurons, S88 improves survival and reduces tunicamycin-induced ER-stress markers.”
Cellstunicamycin-induced ER stressSH-SY5Y-derived neurons
Discovery of a pyrazolopyridine alkaloid that mitigates neuronal ER stress and age-related decline
Communications biology8 May 2026
Neuronal survival
upin human cells1
1 study
Neuronal survival
upin human cells1
S88 increases neuronal survival in human cells.
“In human SH-SY5Y-derived neurons, S88 improves survival and reduces tunicamycin-induced ER-stress markers.”
CellsSH-SY5Y-derived neurons
Discovery of a pyrazolopyridine alkaloid that mitigates neuronal ER stress and age-related decline
Communications biology8 May 2026