In mice and mouse cells, disrupting TET enzymes allowed rare pre-existing aneuploid subclones, including chromosome 17 trisomy, to dominate during rapid cellular…In mice and mouse cells, disrupting TET enzymes allowed rare pre-existing aneuploid subclones, including chromosome 17 trisomy, to dominate during rapid cellular expansion.
Increasing histone 3 lysine 9 methylation reduced leukemogenesis in both young and aged murine cells.Increasing histone 3 lysine 9 methylation reduced leukemogenesis in both young and aged murine cells.