2 papers3 findings
IL-6, TNF-α, and C-reactive protein
upin humans1
Appetite loss is associated with IL-6, TNF-α, and C-reactive protein in humans.
“and had higher IL-6, TNF-α, and CRP levels (p < 0.001 for each).”
Humansimpaired versus good appetitebaselinen = 3,073
Poor appetite and inflammation linked to mobility loss
Journal of the American Geriatrics Society12 Oct 2026
Persistent lower extremity limitation
upin humans1HR 1.44
Appetite loss is associated with persistent lower extremity limitation in humans (adjusted HR 1.44, 95% CI 1.2–1.7).
“Subjects with impaired appetite experienced a higher risk of developing PLL (hazard ratio, adjusted = 1.44; 95% CI = 1.2, 1.7)”
Humansimpaired versus good appetite; adjusted analysisup to 6 yearsn = 3,073
Poor appetite and inflammation linked to mobility loss
Journal of the American Geriatrics Society12 Oct 2026
Physical function
downin humans1
Appetite loss is associated with physical function in humans.
“most studies indicate that older adults with poor appetite tended to exhibit poor physical performance and increased functional limitations.”
Review
Appetite loss as a clinical marker of loss of function during ageing
The Proceedings of the Nutrition Society15 Sep 2025
Over up to six years, 64% of participants aged 70–79 with poor appetite developed lasting mobility difficulties, compared with 47% with good appetite.Over up to six years, 64% of participants aged 70–79 with poor appetite developed lasting mobility difficulties, compared with 47% with good appetite.