Epigenetic age and DunedinPACE

Biomarker

1 paper1 finding

Associations

Plasmapheresis

upin humans1

1 study

Plasmapheresis is associated with epigenetic age and DunedinPACE in humans (~+0.16–0.26 years per session across GrimAge-family clocks; ~0.003±0.001 DunedinPACE units per session).
“repeated plasmapheresis in donors was associated with increases in several clocks and DunedinPACE per procedure”
ReviewPlasma donorsrepeated procedures
Epigenetics of Aging in Mammals: Mechanistic Foundations and Intervention Effects on DNA Methylation–Based Aging Biomarkers
Preprints.org10 Mar 2026Preprint

Latest

4 in 12 months

Neurology Open Access4 Oct

Epigenetic age links to higher dementia risk in older adults

In 2,606 participants, higher DunedinPACE was associated with increased risks of mild cognitive impairment (hazard ratio 1.16) and all-cause dementia (hazard ratio 1.30).In 2,606 participants, higher DunedinPACE was associated with increased risks of mild cognitive impairment (hazard ratio 1.16) and all-cause dementia (hazard ratio 1.30).

Cohort study of 2,606 peopleAll-cause dementia

Paper

Frontiers in Aging22 Sep