Frontiers in Immunology
Age-linked enzyme decline may weaken mouse T cell responses
In laboratory experiments, increasing the enzyme’s production improved activation and raised immune-response molecule levels in T cells from mice aged 18–22 months.In laboratory experiments, increasing the enzyme’s production improved activation and raised immune-response molecule levels in T cells from mice aged 18–22 months.
Animal cell studyImmune response
Who was studiedT cells isolated from mice, against aged cells without PDHK1 overexpression
What changedIncreasing PDHK1 improved activation and immune-response molecule expression in aged mouse T cells compared with cells without overexpression
The catchProtection against infection or cancer in living animals was not measured