Electronic frailty index
Biomarker2 papers5 findings
- Humans2
Interventions
1Anticholinergic agents
no changein humans1Low certainty
1 study
Anticholinergic agents
no changein humans1Low certainty
Anticholinergic agents have no effect on electronic frailty index in humans.
Humanscompared with β3-agonist use in overactive bladder5 yearsfemales
Anticholinergics link to higher dementia risk in older women · International journal of urology : official journal of the Japanese Urological Association · 1 Oct 2026
Effects
3Days alive and out of hospital in the first 30 days
downin humans1
1 study
Days alive and out of hospital in the first 30 days
downin humans1
Electronic frailty index decreases days alive and out of hospital in the first 30 days in humans (β= -3.79, p<0.01).
Humansin older adults receiving CAR-T therapyn = 260
Electronic frailty index predicts CAR-T outcomes in older adults · Blood advances · 2 Oct 2026
Event-free survival
downin humans1HR 2.02
1 study
Event-free survival
downin humans1HR 2.02
Electronic frailty index decreases event-free survival in humans (HR=2.02, p<0.01).
Humansin older adults receiving CAR-T therapyn = 260
Electronic frailty index predicts CAR-T outcomes in older adults · Blood advances · 2 Oct 2026
Overall survival
downin humans1HR 1.64
1 study
Overall survival
downin humans1HR 1.64
Electronic frailty index decreases overall survival in humans (HR=1.64, p<0.05).
Humansin older adults receiving CAR-T therapyn = 260
Electronic frailty index predicts CAR-T outcomes in older adults · Blood advances · 2 Oct 2026
Associations
1Grade 3+ toxicity
upin humans1OR 4.84
1 study
Grade 3+ toxicity
upin humans1OR 4.84
Electronic frailty index raises the risk of grade 3+ toxicity in humans (OR=4.84, p<0.01).
Humansin older adults receiving CAR-T therapyn = 260
Electronic frailty index predicts CAR-T outcomes in older adults · Blood advances · 2 Oct 2026
Latest
2Electronic frailty index predicts CAR-T outcomes in older adults
Very frail older patients had worse overall survival (HR=1.64) and event-free survival (HR=2.02) after CAR-T therapy than robust or prefrail peers.Very frail older patients had worse overall survival (HR=1.64) and event-free survival (HR=2.02) after CAR-T therapy than robust or prefrail peers.
Anticholinergics link to higher dementia risk in older women
Anticholinergic use was associated with higher incident dementia risk compared with β3-agonist use (hazard ratio, 1.49; 95% CI, 1.04–2.13).Anticholinergic use was associated with higher incident dementia risk compared with β3-agonist use (hazard ratio, 1.49; 95% CI, 1.04–2.13).