Dysfunctional regulatory T cells

1. Candida induces dysfunctional regulatory T cells in human cells.

   “Candida can induce both proliferation and dysfunction of Tregs in an IL-6 dependent manner”

   Cellsin vitro, IL-6 dependent

   Enrichment of Candida associated with dysbiosis contributes to mucosal CD4⁺FOXP3⁺ regulatory T cell accrual and their dysfunction in aging

   Frontiers in immunology·19 Mar 2026

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1. Candida is associated with dysfunctional regulatory T cells in humans.

   “abundance of Candida is positively correlated with elevated levels of mucosal Tregs, dysfunctional Tregs (TregDys), and hyperactivated CD4+ T cells.”

   Humansoral mucosa

   Enrichment of Candida associated with dysbiosis contributes to mucosal CD4⁺FOXP3⁺ regulatory T cell accrual and their dysfunction in aging

   Frontiers in immunology·19 Mar 2026

More on Candida