Acta Neuropathologica
Protein mutation worsened age-related brain damage
A Parkinson’s-linked change in the CHCHD2 protein worsened nerve-fiber damage and problems with thinking.A Parkinson’s-linked change in the CHCHD2 protein worsened nerve-fiber damage and problems with thinking.
Mouse studyMechanisms
Who was studiedAged transgenic and wild-type mice
What changedAged mutant-protein mice had a near 2-fold increase in degenerating brain axons versus wild-type and normal-protein transgenic mice
The catchDifferent protein levels between mutant and normal transgenic mice complicate attribution to the mutation