Dopamine uptake
2 papers2 findings
- Animals2
Upstream
2LRRK2
downin mice1
1 study
LRRK2
downin mice1
LRRK2 decreases dopamine uptake in mice.
“striatal synaptosomes isolated from young mutant mice exhibited significantly lower dopamine uptake after rotenone toxicity”
Animalsafter rotenone toxicitystriatum
Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson's disease
Scientific reports18 Jan 2017
Wistar-Kyoto strain
downin rats1
1 study
Wistar-Kyoto strain
downin rats1
Wistar-Kyoto strain decreases dopamine uptake in rats.
“Also only in Wistar-Kyotos dopamine uptake was reduced in the aged striatum, but in the septum it remained unchanged in both strains.”
Animalsin aged Wistar-Kyotosstriatum
Brain research7 Apr 1987
Latest
Scientific Reports
Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson's disease
Experiments in miceMechanisms
PLOS One
Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function
Experiments in miceMechanisms
Brain Research
Age-related reductions in brain cholinergic and dopaminergic indices in two rat strains differing in longevity
Experiments in ratsMechanisms