CSF p62/SQSTM1

1. CSF p62/SQSTM1 is associated with incident dementia in humans (highest versus lowest quartile of CSF p62/SQSTM1) (HR 1.78, 95% CI 1.16–2.73; Q4 versus Q1).

   “participants in the highest quartile (Q4) exhibited an increased risk compared to the lowest (Q1) (HR = 1.78, 95% CI 1.16-2.73).”

   Humanshighest versus lowest quartile of CSF p62/SQSTM1cerebrospinal fluid

   Cerebrospinal fluid p62/SQSTM1 is associated with tau pathology, brain structural alterations, and cognitive impairment in adults without dementia

   Journal of Alzheimer's disease : JAD·Oct 30, 2026

More on Incident dementia

1. CSF p62/SQSTM1 is associated with whole brain volume in humans (dementia-free participants).

   “Elevated CSF p62/SQSTM1 levels correlated with poorer cognition, heightened tau pathology, increased sTREM2 and PGRN levels, and decreased whole-brain and fusiform gyrus volumes.”

   Humansdementia-free participantsbrainn = 557

   Cerebrospinal fluid p62/SQSTM1 is associated with tau pathology, brain structural alterations, and cognitive impairment in adults without dementia

   Journal of Alzheimer's disease : JAD·Oct 30, 2026

1. CSF p62/SQSTM1 is associated with sTREM2 in humans (dementia-free participants).

   “Elevated CSF p62/SQSTM1 levels correlated with poorer cognition, heightened tau pathology, increased sTREM2 and PGRN levels”

   Humansdementia-free participantscerebrospinal fluidn = 557

   Cerebrospinal fluid p62/SQSTM1 is associated with tau pathology, brain structural alterations, and cognitive impairment in adults without dementia

   Journal of Alzheimer's disease : JAD·Oct 30, 2026

More on sTREM2

1. CSF p62/SQSTM1 is associated with tau pathology in humans (dementia-free participants).

   “Elevated CSF p62/SQSTM1 levels correlated with poorer cognition, heightened tau pathology”

   Humansdementia-free participantscerebrospinal fluidn = 557

   Cerebrospinal fluid p62/SQSTM1 is associated with tau pathology, brain structural alterations, and cognitive impairment in adults without dementia

   Journal of Alzheimer's disease : JAD·Oct 30, 2026

1. CSF p62/SQSTM1 is associated with cognitive function in humans (dementia-free participants).

   “Elevated CSF p62/SQSTM1 levels correlated with poorer cognition”

   Humansdementia-free participantscerebrospinal fluidn = 557

   Cerebrospinal fluid p62/SQSTM1 is associated with tau pathology, brain structural alterations, and cognitive impairment in adults without dementia

   Journal of Alzheimer's disease : JAD·Oct 30, 2026