Whole brain volume
2 papers2 findings
- Humans2
Interventions
1Chronic pain
downin humans2
2 studies
Chronic pain
downin humans2
Chronic pain decreases whole brain volume in humans.
“Moderate‐to‐severe chronic pain relative to mild or none was associated with accelerated decline in global cognition (increase in CDR‐SB: b = .05), memory, executive function (b=‐.04), and whole brain volume (b=‐.02)”
Humansrelative to mild or none
AAIC 2025 abstract25 Dec 2025
Chronic pain decreases whole brain volume in humans (b=-.02, p < .05).
“whole brain volume (b=‐.02), and faster accumulation of Aβ pathology (CSF Aβ42 decline: b=‐.07, all p ’s < .05).”
Humansrelative to mild or none
AAIC 2025 abstract23 Dec 2025
Latest
4 in 12 monthsBrain Communications
Long-term brain volume trajectories and lifestyle associations in cognitively normal adults: the BRAIN-STRIDE study
Cohort study of 653 peoplePopulations
AAIC 2025 Abstract
Association of Moderate‐to‐Severe Chronic Pain with Cognitive Decline and Alzheimer's Biomarkers in the Alzheimer's Disease Neuroimaging Initiative
Cohort study of 2,487 peopleChronic pain
AAIC 2025 Abstract
Association of Moderate‐to‐Severe Chronic Pain with Cognitive Decline and Alzheimer’s Biomarkers in the Alzheimer’s Disease Neuroimaging Initiative
Cohort study of 2,487 peopleChronic pain
AAIC 2025 Abstract
Associations of frailty with neuropsychiatric symptoms of Alzheimer's Disease: a longitudinal study
Cohort study of 2,155 peopleAlzheimer's disease