Core body temperature

1. Caloric restriction decreases core body temperature in humans (P<.05).

   “Core body temperature was reduced in the calorie restriction and calorie restriction with exercise groups (both P<.05).”

   Human trial6 monthsn = 48

   Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial

   JAMA·5 Apr 2006

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1. Melatonin decreases core body temperature in humans.

   “The EARLY and LATE treatments yielded significant and unambiguous reductions in core body temperature.”

   Human trialEARLY (30 minutes before bedtime) and LATE (4 hours after bedtime) treatments in age-related sleep-maintenance insomniaimmediate-release0.5 mg2-week trials

   The role of melatonin and circadian phase in age-related sleep-maintenance insomnia: assessment in a clinical trial of melatonin replacement

   Sleep·1 Jan 1998

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1. Leucine enkephalin is associated with core body temperature in mice.

   “leucine enkephalin directly controls core body temperature when exogenously injected into the hypothalamus”

   Animalshypothalamus

   Metabolic adaptation to calorie restriction

   Science signaling·8 Sep 2020

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