Papers on constipation

331 papers19 new in 30 days

Saturday, November 14

Preprints.orgNov 14

Nutritional Strategies for Managing Gastrointestinal Adverse Effects Associated with GLP-1 Receptor Agonist and Dual GIP/GLP-1 Receptor Agonist Therapy: A Narrative Review with Practical Recommendations

Preprint: reviewGLP-1 receptor agonists

Thursday, November 12

The Lancet Gastroenterology & HepatologyNov 12

Safety and efficacy of weekly pemvidutide versus placebo for metabolic dysfunction-associated steatohepatitis (IMPACT): 48-week results from a multicentre, randomised, double-blind, phase 2b study

Figure from The Lancet Gastroenterology & Hepatology

Randomized trial in 212 peopleMetabolic dysfunction-associated steatohepatitis

Wednesday, November 11

Research SquareNov 11

An index of oral-type gut genera is associated with lower muscle mass and with 3- year muscle loss in community-dwelling older adults: a cohort study

Muscle measures across tertiles of the oral-type genera index, and the association of the index with 3-year change in appendicular skeletal muscle mass.

Preprint: cohort study of 782 peopleMuscle

Research SquareNov 11

Safety and efficacy of oral non-peptide GLP-1 receptor agonist in non- diabetic obese patients; systematic review and meta-analysis of randomized controlled trials

Preprint: meta-analysis of randomized trialsGLP-1 receptor agonists

CureusNov 11

Efficacy and Safety of Oral Orforglipron for Weight Reduction in Adults With Overweight or Obesity: A Systematic Review

PRISMA 2020 flow diagram of study selection.

Systematic review of randomized trialsOrforglipron

European Journal of Case Reports in Internal MedicineNov 11

Iatrogenic Hypercalcemia in A Patient with Type 2 Diabetes and Chronic Kidney Disease

Case reportChronic kidney disease

European Journal of Obstetrics, Gynecology, and Reproductive BiologyNov 11

Polypharmacy and the ageing brain: Anticholinergic burden in the ageing population and the impact of gynaecological medications

ReviewPolypharmacy

Tuesday, November 10

BMC GastroenterologyNov 10

Constipation-linked death rates rose in the United States

Death rates adjusted for age rose from 0.26 in 1999 to 0.55 in 2024, with faster increases among men.Death rates adjusted for age rose from 0.26 in 1999 to 0.55 in 2024, with faster increases among men.

Overall and sex-stratified age-adjusted mortality rates (per 100,000) for constipation-associated mortality among US adults aged ≥ 25 years, 1999–2024, with the provisional 2025 value shown as a…

Cross-sectional · 22,237 peopleConstipation

Sunday, November 8

CureusNov 8

Rapid Eye Movement Sleep Behavior Disorder as a Prodromal Manifestation of Alpha-Synucleinopathies

ReviewMechanisms

Saturday, November 7

Diabetes Research and Clinical PracticeNov 7

Phase 3 clinical development of semaglutide (2015-2026): a comprehensive evidence-based review of trial designs, therapeutic outcomes and global clinical experience

Figure from Diabetes Research and Clinical Practice

ReviewSemaglutide

Sunday, November 1

Psychiatry and Clinical PsychopharmacologyNov 1

Are Incretin Receptor Agonists Psychiatric Drugs: Near-term Opportunity or Creative Superlative?

ReviewGLP-1 receptor agonists

Friday, October 30

Frontiers in NeurologyOct 30

Early Parkinson’s linked to family history and autoimmune disease

Family history was linked to a hazard ratio—a measure comparing disease rates over time—of 4.03 for early-onset Parkinson’s compared with no family history.Family history was linked to a hazard ratio—a measure comparing disease rates over time—of 4.03 for early-onset Parkinson’s compared with no family history.

A group of people surrounds a smaller pale group, beside neurons with full and sparse branches and immune cells clustered against damaged tissue.

Cohort · 283,934 peopleParkinson's disease

Thursday, October 29

Frontiers in MicrobiomesOct 29

Pharmacomicrobiomics of GLP-1 receptor agonist gastrointestinal tolerability: integrating host genetics and the gut microbiome

Figure from Frontiers in Microbiomes

ReviewGLP-1 receptor agonists

Tuesday, October 27

CureusOct 27

Ischemic Colitis in the Setting of Tirzepatide Use: A Potentially Underrecognized Adverse Effect

Computed tomography of the abdomen and pelvis demonstrating significant colonic distension in the cecum, ascending, descending, and sigmoid colon with mesenteric induration in the anterior-posterior…

Case reportTirzepatide

Monday, October 26

Drugs & AgingOct 26

Comparative Impact of Anticholinergic Exposure, Potentially Inappropriate Medications, and Polypharmacy on Clinical Outcomes: A Nationwide Claims Database Study in Japan

Figure from Drugs & Aging

Case-control study in peoplePopulations

Zhonghua Wei Chang Wai Ke Za ZhiOct 26

Efficacy and safety of GLP-1 receptor agonists combined with bariatric surgery for obesity: a timing-stratified systematic review

Meta-analysisGLP-1 receptor agonists

Saturday, October 24

European Journal of Clinical PharmacologyOct 24

Efficacy and safety of GLP-1 receptor agonists for antipsychotic-related overweight and metabolic dysregulation: a systematic review and meta-analysis

Figure from European Journal of Clinical Pharmacology

Meta-analysis of randomized trialsGLP-1 receptor agonists

Monday, October 19

Neurogastroenterology and MotilityOct 19

Gastrointestinal Symptom Events and Motility Alterations Associated With GLP-1 Receptor Agonists

Figure from Neurogastroenterology and Motility

Cohort study of 78,277 peoplePopulations

Sunday, October 18

Clinical and Experimental NephrologyOct 18

The coexistence of constipation and diarrhea is associated with the development of chronic kidney disease: a 10-year cohort study

Figure from Clinical and Experimental Nephrology

Cohort study of 14,876 peopleChronic kidney disease

Friday, October 16

HealthcareOct 16

Real-World Anthropometric Outcomes, Safety, and Use Patterns of GLP-1 and Dual GIP/GLP-1 Receptor Agonists in Obesity and Glucose Metabolism Disorder: A Nationwide Multicentre Community Pharmacy Study

Flow diagram of participant recruitment, study inclusion, and analytical populations.

Cross-sectional study of 531 peopleGLP-1 receptor agonists

Wednesday, October 14

Acta Gastroenterologica LatinoamericanaOct 14

Glucagon-Like Peptide-1 Receptor Agonist and Gastrointestinal Adverse Effects: A Comprehensive Review

Central and Peripheral Mechanisms Underlying the Therapeutic and Gastrointestinal Adverse Effects of GLP-1 Receptor Agonists

ReviewGLP-1 receptor agonists

Tuesday, October 13

Geriatrics & Gerontology InternationalOct 13

Association Between CT-Based Rectal Stool Attenuation and Activities of Daily Living in Hospitalized Older Adults

Timeline of clinical assessment.

Cross-sectional study of 116 peopleBiomarkers

Clinical Nutrition ESPENOct 13

Characterizing the Adverse Event Profile of Semaglutide: A Comprehensive U.S. Food and Drug Administration Adverse Event Reporting System-Based Pharmacovigilance Study

Figure from Clinical Nutrition ESPEN

Cross-sectional study of 43,754 peopleSemaglutide

Sunday, October 11

Biology Methods & ProtocolsOct 11

Comparison of cardiometabolic benefits and tolerability in patients on sustained low doses of semaglutide or tirzepatide

Cohort funnels for sustained lowest-dose semaglutide and tirzepatide as real-world proxies for microdosing.

Cohort study of 1,016 peopleTirzepatide

Saturday, October 10

Chinese General PracticeOct 10

Evaluation and Comparison of Multidimensional Functional Disability in Geriatric Comorbidities and Comorbid Acute Kidney Injury

Cross-sectional study of 114 peopleAcute kidney injury

Friday, October 9

MedicineOct 9

Shared genetic architecture between constipation and aging-related phenotypes: Insights from large-scale genome-wide cross-trait analysis

The Shared Genetic Atlas of Constipation and Aging Phenotypes.

Computational studyMechanisms

Wednesday, September 16

Journal of PsychopharmacologySep 16

Adjunctive GLP-1 receptor agonists for cardiometabolic risk in antipsychotic-treated patients: A GRADE-assessed meta-analysis of randomized trials

Meta-analysis of randomized trialsGLP-1 receptor agonists

Thursday, September 3

Research SquareSep 3

Defecation Frequency, Stool Form, and Comprehensive Frailty in Community-Dwelling Older Adults: A Cross-Sectional Study

Associations between defecation frequency and Kihon Checklist subdomain impairments in all participants and no-medication analysis.

Preprint: cross-sectional study of 267 peoplePopulations

Saturday, August 29

Frontiers in Public HealthAug 29

Geriatric syndromes and intrinsic capacity in older adults with coronary heart disease: a cross-sectional study in China

Study flowchart.

Cross-sectional study of 5,835 peopleCoronary artery disease

Frontiers in EndocrinologyAug 29

Clinical efficacy of tirzepatide for weight regain and suboptimal glycemic control following laparoscopic sleeve gastrectomy: a case series of three patients with obesity-associated type 2 diabetes

Longitudinal clinical courses of the three cases following LSG.

Case seriesTirzepatide