Clusterin

Biomarker

3 papers2 findings

MeSH D051152

Animals2

Interventions

3,3-dimethyl-1-butanol

downin mice1

1 study

3,3-dimethyl-1-butanol decreases clusterin in mice.
“the effects obtained after treatment with DMB were accompanied by a reduction in circulating clusterin levels and hippocampal neuroinflammatory status in APP/PS1 mice.”
AnimalsAPP/PS1 mice
Decreased levels of circulating trimethylamine N-oxide alleviate cognitive and pathological deterioration in transgenic mice: a potential therapeutic approach for Alzheimer's disease
Aging14 Oct 2019

Associations

Amyloid-beta deposition

upin humans1

1 study

Clusterin predicts amyloid-beta deposition in humans.
“elevated plasma levels of CLU in healthy older adults may precede significant Aβ deposition in the brain by as much as ten years”
Review
Clusterin as a biomarker for Alzheimer's disease
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2026

Latest

5 in 12 months

bioRxiv2 Oct

Membrane attack complex deposits on pericytes in human eyes

Single-cell analysis of four aged human donor eyes revealed complement membrane attack complexes concentrated primarily on pericytes, smooth muscle cells, and…Single-cell analysis of four aged human donor eyes revealed complement membrane attack complexes concentrated primarily on pericytes, smooth muscle cells, and macrophages.

Preprint: cross-sectional study of 4 peoplePlasma membrane

Paper

Zhurnal Nevrologii I Psikhiatrii Imeni S.S Korsakova7 Aug