3,3-dimethyl-1-butanol

4 papers6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: National Center for Advancing Translational Sciences and 2 more

Animals4

Outcomes

Endothelium-dependent dilation

upin mice1

1 study

3,3-dimethyl-1-butanol improves endothelium-dependent dilation in mice (peak: 90±2%).
“treatment with 3,3-dimethyl-1-butanol for 8 to 10 weeks to suppress trimethylamine-N-oxide selectively improved endothelium-dependent dilation in old mice to young levels (peak: 90±2%)”
Animals8 to 10 weeks
Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans
Hypertension (Dallas, Tex. : 1979)10 Jun 2020

Inflammation

downin mice1

1 study

3,3-dimethyl-1-butanol decreases inflammation in mice.
“the effects obtained after treatment with DMB were accompanied by a reduction in circulating clusterin levels and hippocampal neuroinflammatory status in APP/PS1 mice.”
AnimalsAPP/PS1 micehippocampus
Decreased levels of circulating trimethylamine N-oxide alleviate cognitive and pathological deterioration in transgenic mice: a potential therapeutic approach for Alzheimer's disease
Aging14 Oct 2019