Effect sizes of aerobic exercise and cognitive training interventions on blood biomarkers over 6 months in the ACT Trial

Abstract

Background: It remains unclear whether blood biomarkers of Alzheimer's disease are surrogate endpoints for non‐pharmacological interventions. The ACT Trial blood biomarker study aimed to evaluate neuropathological, neurotrophic, and neuroinflammation biomarkers as surrogate outcomes in older adults with mild cognitive impairment (MCI).