Cell cycle inhibitor

1 paper

Animals1

Latest

17 in 12 months

Diabetologia12 Oct

Genetic background shapes cell aging and diabetes in male mice

Male mice carrying the same diabetes-linked mutation developed diabetes on a mixed genetic background, but maintained normal blood sugar on another background.Male mice carrying the same diabetes-linked mutation developed diabetes on a mixed genetic background, but maintained normal blood sugar on another background.

Experiments in miceMechanisms

Aging9 Oct

Tiny vesicles spread senescence in lab-grown human cells

In lab-grown human fibroblasts, tiny vesicles from senescent cells prompted dividing cells to halt division and activate a DNA damage response.In lab-grown human fibroblasts, tiny vesicles from senescent cells prompted dividing cells to halt division and activate a DNA damage response.

Experiments in human cellsCellular senescence

Frontiers in Pharmacology18 Sep

Targeting skin aging: anti-senescent potential and key enzyme modulation of Lavandula essential oils

Experiments in cellsSkin

Biogerontology24 Aug

Formononetin attenuates cellular senescence through a FOS-mediated mechanism

Experiments in human cellsInterventions

bioRxiv18 Aug

HDAC4/5 regulate epidermal barrier function by modulating the epigenetic landscape of human keratinocytes

Preprint: experiments in human cellsCell cycle regulation

Bioengineering & Translational Medicine5 Aug

Rapamycin-nanoliposomes target the mTORC1-mediated autophagy-lysosomal and NLRP3/Caspase-1 pathways to inhibit nucleus pulposus cell senescence in intervertebral discs

Experiments in rat cellsmTOR inhibitors

The EMBO Journal7 Jul

SenFlag gene signature identifies senescent cells in mouse and human tissues through a conserved core transcriptional program

Computational studyBiomarkers

Theranostics29 Jun

Cellular senescence in musculoskeletal diseases: biological mechanisms and clinical implications

ReviewCellular senescence

Cell Communication and Signaling7 May

Environmental pollutant BDE-47 alters glycan and microRNA signatures of macrophage-derived extracellular vesicles and modulates senescence signaling

Experiments in human cellsCellular senescence

Arteriosclerosis, Thrombosis, and Vascular Biology12 Mar

Pulmonary Vascular Signaling in Pulmonary Hypertension: Potential Role of Endothelial Ca²⁺ Signaling in Cellular Senescence and Inflammasome Activation

ReviewNLRP3 inflammasome