CD8+ central memory T cell frequency

1. Metformin increases CD8+ central memory T cell frequency in human cells.

   “In vitro treatment with 20 mM metformin for 24 hours increased the frequency of CD8+Tcm cells”

   CellsPBMCs20 mM24 hours

   Metformin promotes the expansion of CD8+ central memory T cells by offsetting Pentose phosphate pathway

   Research Square·15 Oct 2026Preprint

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