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Senescence-associated secretory proteins

Intervention

1 paper studies it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab
  • Animals1

Outcomes

2

CD38 expression

upin cells1

1 study

  1. Senescence-associated secretory proteins increase CD38 expression in cells.

    “inflammatory cytokines found in the supernatant from senescent cells (Senescence associated secretory proteins, SASP) induce macrophages to proliferate and to express CD38.”

    Cellssenescent-cell supernatantmacrophage

    Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38 + pro-inflammatory macrophages

    bioRxiv (Cold Spring Harbor Laboratory)Apr 17, 2019Preprint

More on CD38 expression

Macrophage proliferation

upin cells1

1 study

  1. Senescence-associated secretory proteins induce macrophage proliferation in cells.

    “inflammatory cytokines found in the supernatant from senescent cells (Senescence associated secretory proteins, SASP) induce macrophages to proliferate and to express CD38.”

    Cellssenescent-cell supernatantmacrophage

    Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38 + pro-inflammatory macrophages

    bioRxiv (Cold Spring Harbor Laboratory)Apr 17, 2019Preprint

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