What does the research say about cardiomyocyte proliferation?

Cardiomyocyte proliferation

There are 4 papers on cardiomyocyte proliferation in aging research: none in people yet, 3 in animals, 1 in cells. The newest story, Nov 1, 2026: “Exercise-linked protein promotes heart regeneration in mice”.

Biomarker

4 papers study it40 more mention it

4 new papers in 30 daysSee all 44 papers on cardiomyocyte proliferation

Animals3
Cells1

Latest

14 papers in 12 months

Mechanisms of Ageing and DevelopmentDec 3

Senolytics rejuvenate aging cardiomyopathy in human cardiac organoids

Experiments in human cellsSenolytics

Paper

Oxidative Medicine and Cellular LongevityMay 14

Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation

Experiments in ratsSpermidine

Paper

Journal of Molecular MedicineSep 28

MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents

Experiments in miceAngiogenesis

Paper

Cell ReportsNov 1

Exercise-linked protein promotes heart regeneration in mice

Experiments in adult mice found that giving clusterin, a protein increased by exercise, promoted heart regeneration after a heart attack.Experiments in adult mice found that giving clusterin, a protein increased by exercise, promoted heart regeneration after a heart attack.

Mouse studyExercise

Paper

ESC Congress 2026 AbstractOct 26

Immune cell group helps repair hearts in newborn mice

Experiments in newborn mice found that removing these cells reduced heart muscle cell multiplication and worsened inflammation and scarring after heart attacks.Experiments in newborn mice found that removing these cells reduced heart muscle cell multiplication and worsened inflammation and scarring after heart attacks.

Mouse studyBlood and immune system

Paper

Nature CommunicationsOct 20

Two immune responses aid heart regrowth in surface-dwelling fish

Researchers compared regenerating surface-dwelling Mexican cavefish with scar-forming cave-dwelling fish, then disrupted immune activity to test its role in repair.Researchers compared regenerating surface-dwelling Mexican cavefish with scar-forming cave-dwelling fish, then disrupted immune activity to test its role in repair.

Fish studyImmune response

Paper

bioRxivOct 16

Network-enabled drug repurposing identifies lithium to promote cardiomyocyte proliferation

Preprint: experiments in miceLithium

Paper

bioRxivSep 11

Blocking a receptor lets a hormone spur mouse heart cell division

Experiments in newborn mouse heart cells found that blocking one hormone receptor allowed corticosterone to promote division through another, with effects depending on…Experiments in newborn mouse heart cells found that blocking one hormone receptor allowed corticosterone to promote division through another, with effects depending on surrounding cells.

Preprint: animal cell studyMechanisms

Paper

Cell RegenerationAug 11

Small-molecule cocktail 2SM promotes heart regeneration via inducing embryonic-like cardiomyocyte state

Experiments in animalsInterventions

Paper

Nature Cardiovascular ResearchAug 6

Lower workload spurred heart muscle cell division in animals

Animal transplant experiments kept adult hearts supplied with blood but not pumping, prompting heart muscle cells to multiply.Animal transplant experiments kept adult hearts supplied with blood but not pumping, prompting heart muscle cells to multiply.

Animal studyInterventions

Paper

See all 44 papers on cardiomyocyte proliferation

Cardiomyocyte proliferation

Latest

Related