Cardiac proteome

1 paper

Human trial1

Latest

3 in 12 months

Journal of the American Heart Association28 Apr

Cardiomyocyte-Specific Plakophilin-2 Loss Is Sufficient to Induce Aging and Senescence of Nonmyocytes: Relevance to Arrhythmogenic Cardiomyopathy

Experiments in miceCellular senescence

bioRxiv27 Apr

Senescence and DNA Damage-Induced Inflammation Drive Heart Failure with Preserved Ejection Fraction in Cardiovascular Kidney Metabolic Syndrome

Preprint: experiments in miceHeart failure with preserved ejection fraction

Aging Cell22 Apr

Multi-Omics Reveals Mechanisms of Metabolic Rejuvenation in Aged Mice and Pre-Frail Older Men by Losartan

Trial in peopleInterventions

bioRxiv24 Nov

Cardiomyocyte-specific plakophilin-2 loss is sufficient to induce aging and senescence of nonmyocytes. Relevance to arrhythmogenic cardiomyopathy

Preprint: experiments in miceCellular senescence

GSA 2024 Abstract1 Jan

GLYNAC AND THE AGING MOUSE HEART: SEX-RELATED DIFFERENCES AND OUTCOMES

Experiments in miceInterventions

Journal of Advanced Research12 May

Sodium-glucose exchanger 2 inhibitor canagliflozin promotes mitochondrial metabolism and alleviates salt-induced cardiac hypertrophy via preserving SIRT3 expression

Experiments in animalsInterventions

The Journal of Clinical Investigation1 May

Cirbp suppression compromises DHODH-mediated ferroptosis defense and attenuates hypothermic cardioprotection in an aged donor transplantation model

Experiments in animalsInterventions

Nature Aging22 Dec

Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs

Experiments in fliesMechanisms

American Journal of Physiology Heart and Circulatory Physiology6 Aug

Proteogenomics reveals sex-biased aging genes and coordinated splicing in cardiac aging

Experiments in animalsMechanisms

Science Translational Medicine17 Jun

Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart

Experiments in monkeysInterventions