Cardiac function
Biomarker1 paper
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56Ventricular-Arterial Coupling in Endurance-Trained Athletes and Sedentary Adults
Inhibiting miR-128-3p restores muscle mass and function in aged mice
The microRNA inhibitor also improved cardiac outcomes after infarction and reduced pathology in mouse and pig models of muscular dystrophy.The microRNA inhibitor also improved cardiac outcomes after infarction and reduced pathology in mouse and pig models of muscular dystrophy.
Exercise prevents doxorubicin-induced cardiac senescence in mice
In transgenic mice, exercise prevented doxorubicin-induced cardiotoxicity and senescence while maintaining cardiac FNDC5 levels, with irisin blunting…In transgenic mice, exercise prevented doxorubicin-induced cardiotoxicity and senescence while maintaining cardiac FNDC5 levels, with irisin blunting senescence in cultured human cells.
Lack of the AT2R receptor accelerates cardiac senescence and fibrosis in aging mice
Mice lacking the receptor also showed higher inflammation, elevated DNA damage, and a five-month reduction in median lifespan.Mice lacking the receptor also showed higher inflammation, elevated DNA damage, and a five-month reduction in median lifespan.