CAD PRS

1. CAD PRS has no effect on incident CAD risk prediction in humans (change in AUC <= 0.002, P > 0.6).

   “neither Lp(a) nor CAD-PRS improved prediction of incident CAD beyond the SMART score”

   Humansbeyond SMART score in ischemic stroke survivors without baseline CAD

   Lipoprotein(a) and Coronary Artery Disease Polygenic Risk Scores Do Not Improve Secondary Manifestations of Arterial Disease Score Prediction of Coronary Events After Ischemic Stroke

   Journal of the American Heart Association·10 Oct 2026

1. CAD PRS raises the risk of coronary artery disease in humans (2.32 (95% CI 2.05-2.63)).

   “Relative to intermediate, high CAD PRS was associated with 2.32 (95% CI 2.05-2.63) risk for CAD.”

   Humansrelative to intermediate genetic riskfemales

   Premature Menopause and Polygenic Risk on Incident Coronary Artery Disease among Postmenopausal Women

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

2. CAD PRS raises the risk of coronary artery disease in humans (comparable or higher CAD risk).

   “The top 8% of the PRS distribution exhibited comparable or higher CAD risk than FH carriers.”

   Humanstop 8% of the PRS distribution vs FH carriers

   Population Screening for Polygenic Risk Identifies and Prevents More Cases of Coronary Artery Disease Than Screening for FH

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

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