Braak stage V/VI tau neuropathology

Older age decreases Braak stage V/VI tau neuropathology in humans (β=-0.25, p<0.001).

“In autopsy‐analyses (age: 82.7±7.9, 54.7% male), older age and male sex were associated with a lower prevalence of Braak‐V/VI neuropathology (β=‐0.25, p <0.001”

HumansMCI or dementia with moderate-to-frequent CERAD scoresn = 947

Lower Antemortem [ ¹⁸ F]flortaucipir PET retention in Males and Older Individuals is Explained by Lower Postmortem Tau Tangle Density

AAIC 2025 abstract·23 Dec 2025