MechanismsHumans
Lower Antemortem [ ¹⁸ F]flortaucipir PET retention in Males and Older Individuals is Explained by Lower Postmortem Tau Tangle Density
AAIC 2025 Abstract
Abstract
Background: Older age and male sex have been associated with lower Tau‐PET uptake in symptomatic Alzheimer’s disease. We investigated the PET‐to‐neuropathological correlates of age‐ and sex‐effects on tau in independent PET ( N = 680), autopsy ( N = 947), and PET‐to‐autopsy ( N = 84) analyses.
The paper
Emma M. Coomans, Ruben Smith, Daria Pawlik, Rik Ossenkoppele
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Kevin Oliveira Hauer, Sebastian Palmqvist, Michael J. Pontecorvo, Sergey Shcherbinin, Vikas Kotari, Geidy E. Serrano, Thomas G. Beach, Erik Stomrud, Niklas Mattsson, Annemieke J.M. Rozemüller, Wiesje M. van der Flier, Yolande A.L. Pijnenburg, Elsmarieke van de Giessen, Oskar Hansson,Amsterdam Neuroscience · Lund University
AAIC 2025 Abstract · 23 Dec 2025 · CC BY
Presented at AAIC 2025
