Blood-brain barrier water exchange rate

2 papers2 findings

Humans2

Interventions

1

Blood pressure variability

downin humans1

1 study

Blood pressure variability decreases blood-brain barrier water exchange rate in humans (β = -0.180, 95% CI -0.314 to -0.045).
“BPV negatively associated with BBB kw (β = -0.180, 95% CI-0.314 to -0.045, n = 213).”
Humansdementia-free participantsbrainn = 213
Association of 24-Hour Blood Pressure Variability With Cognition and Brain MRI Markers of Structural Change in Adults in Mid- to Late-Life
Neurology30 Apr 2026

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Male sex

downin humans1

1 study

male sex decreases blood-brain barrier water exchange rate in humans.
“which was more pronounced in males. In addition, we observed sex differences in parietal and temporal regions.”
Humansparietal and temporal regionsmales
Age-Related Decline in Blood-Brain Barrier Function is More Pronounced in Males than Females in Parietal and Temporal Regions
bioRxiv : the preprint server for biology31 Jan 2024Preprint

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Neurology30 Apr

Association of 24-Hour Blood Pressure Variability With Cognition and Brain MRI Markers of Structural Change in Adults in Mid- to Late-Life

Cross-sectional study of 225 peopleGlobal cognition

NMR in Biomedicine10 Sep

Measurement of blood-brain barrier water exchange rate using diffusion-prepared and multi-echo arterial spin labelling: Comparison of quantitative values and age dependence

Study in peopleBiomarkers

bioRxiv31 Jan

Age-Related Decline in Blood-Brain Barrier Function is More Pronounced in Males than Females in Parietal and Temporal Regions

Preprint: cross-sectional study of 186 peopleMechanisms