Blood-brain barrier dysfunction

Biomarker

1 paper1 finding

Associations

1

Alzheimer's disease

downin humans1

1 study
  1. Alzheimer's disease is associated with blood-brain barrier dysfunction in humans.

    “both aging and AD are associated with progressive BBB dysfunction contributing to cognitive decline”

    Review

    Imaging markers of neuroinflammation in aging and Alzheimer's disease and related dementia: A comprehensive review

    Neuroscience and biobehavioral reviews25 Jun 2025

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Acta Neuropathologica

Human brain vessels show distinct states in small vessel disease

Researchers identified three vessel states across disease severity by analysing 11,409 vessel fragments from post-mortem brain tissue from 20 cases.Researchers identified three vessel states across disease severity by analysing 11,409 vessel fragments from post-mortem brain tissue from 20 cases.

Cross-sectional study of 20 brain donors across cerebral small vessel disease severitiesMechanisms

Limit: Controls were not age-matched, so ageing could explain disease-associated vascular differences