Beta-cell maturation gene expression

1. CDKN2A is associated with beta-cell maturation gene expression in humans.

   “p16-positive cells express senescence gene signatures, as well as elevated levels of beta-cell maturation genes, consistent with enhanced functionality.”

   Humansp16-positive cellspancreatic beta cell

   Senescence of human pancreatic beta cells enhances functional maturation through chromatin reorganization and promotes interferon responsiveness

   Nucleic acids research·29 Apr 2024

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