Laminin conditional knockout
downin mice1
laminin conditional knockout decreases AQUAPORIN-4 in mice.
“diminished AQP4 level are responsible for BBB disruption in PKO mice.”
Animalsin pericytic laminin conditional knockout micebrain
Pericytic Laminin Maintains Blood-Brain Barrier Integrity in an Age-Dependent Manner
Translational stroke researchJun 18, 2019
Amyloid-beta
upin humans1
AQUAPORIN-4 is associated with amyloid-beta in humans.
“AQP4 and Aβ were positively correlated with each other after adjusting for age in the frontal cortex in both the control and DS groups”
Humansafter adjusting for agefrontal cortex
Neurobiology of diseaseSep 21, 2025
Age
upin humans1
age is associated with AQUAPORIN-4 in humans.
“AQP4 protein levels were higher with age in both neurotypical control and DS groups, but not in the LOAD group.”
Humansneurotypical controls and Down syndromebrain
Neurobiology of diseaseSep 21, 2025
In human imaging and post-mortem brain data, glymphatic impairment occurred in an inflammatory subgroup and tracked with accelerated brain and epigenetic aging.In human imaging and post-mortem brain data, glymphatic impairment occurred in an inflammatory subgroup and tracked with accelerated brain and epigenetic aging.